ADMET/ADMET/MI-QSAR software package shipped as a compressed tar.gz format. To install the software on an SGI workstation, it is necessary to follow the steps listed below. In the following instructions, INSTALLATION_PATH refer the directory where user want to put the ADMET/ADMET/MI-QSAR package. FILE_PATH is the place where the compressed package is kept. All paths must be UNIX absolute path. 

1. Download the file or obtain the file on CD 

Binary distribution of ADMET/ADMET/MI-QSAR package is available through Chem21 Group, Inc. Please contact Professor A. J. Hopfinger regarding availability and licensing issue. Users can either obtain ftp password through Chem21 Group, Inc. to download the software or purchase ADMET/ADMET/MI-QSAR on CD. 

2. Decompress the file 

After user decided which directory would be used for installation, following command should be used to decompress the software: 
Once gunzip process is done, user can do a list using "ls" command and see the new decompressed file miqsar-irix-v1.0.tar 

3. Unpack the directory 

Using the tar utility provided with most distribution of UNIX, users now need to unpack the directory structure of the software. 
The tar file will be expanded into a new folder named MIQSAR_Dist. The second command is simply to clean up the tar file. 

4. Set correct path 

INSTALLATION_PATH>cp /FILE_PATH/miqsar-irix-v1.0.tar.gz . 
INSTALLATION_PATH>gunzip miqsar-irix-v1.0.tar.gz 
INSTALLATION_PATH>tar -xvf miqsar-irix-v1.0.tar 
    INSTALLATION_PATH>rm miqsar-irix-v1.0.tar 

Three files need to be edited to setup the correct environments for ADMET/MI-QSAR to run. They are:
 
A. setpath file; 
B. loadMI.tcl file; and 
C. miqsar executable file 

All these files are text script files and can be opened properly with any text editor. User only need to use the REPLACE function in your text editor to replace all "/INSTALLATION_PATH" with the actual ABSOLUTE path of installation directory, which is the path MIQSAR_Dist directory resides. User can use "pwd" under unix shell the find out the absolute path. 

5. Append the command search path 

All ADMET/MI-QSAR users need to APPEND the executable directory of ADMET/MI-QSAR into UNIX command searching path. In csh, following command can be added into user’s .cshrc file
 
   set path = (/INSTALLATION_PATH/MIQSAR_Dist/bin $path) 

6. Start the program 

To run the program, users are strongly recommended NOT to run any project within installation directory. Project files generated during the process will make the installation directory disorganized. Projects should NOT be run as the root user.
User can either add the installation path to command path through .cshrc or by using alias command to make a shortcut for the miqsar executable. 
Prior to run the ADMET/MI-QSAR program within a user defined working directory, user need to copy over the desired membrane file and associated mpar file from MIQSAR_Dist/membrane directory. 
After these preparation stages, users can start ADMET/MI-QSAR analysis by typing in: 

WORK_DIR>source setpath
WORK_DIR>miqsar.